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Symbol
Name
ID

Trex1
three prime repair exonuclease 1
MGI:1328317

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Increased circulating antibody level

Gastrointestinal hemorrhage

Hematemesis

Hematochezia

Retinal hemorrhage

Purpura

Petechiae

Pancytopenia

Anemia

Hemolytic anemia

Normochromic anemia

Normocytic anemia

Lymphocytosis

Leukopenia

Chronic lymphatic leukemia

Chronic myelomonocytic leukemia

Thrombocytopenia

Neonatal alloimmune thrombocytopenia

Elevated erythrocyte sedimentation rate

Splenomegaly

Hepatosplenomegaly

Disease(s) Associated with TREX1

Aicardi-Goutieres syndrome

Chilblain lupus

retinal vasculopathy with cerebral leukodystrophy

systemic lupus erythematosus

Mouse Phenotypes

thymus cortex hypoplasia

enlarged spleen

increased spleen weight

increased plasma cell number

increased B cell number

increased CD4-positive, alpha-beta T cell number

increased regulatory T cell number

increased spleen B cell follicle size

abnormal spleen marginal zone morphology

increased splenocyte number

increased IgG level

abnormal T cell activation

Availability

Mouse Genotype

Trex1^em3Gpt/Trex1^em3Gpt

Trex1^tm1.1Fwpe/Trex1^tm1.1Fwpe

Trex1^tm1Tld/Trex1^tm1Tld

Trex1^tm1.1Fwpe/Trex1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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